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KMID : 1011820160570050351
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Investigative and Clinical Urology
2016 Volume.57 No. 5 p.351 ~ p.356
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Tamsulosin versus tadalafil as a medical expulsive therapy for distal ureteral stones: A prospective randomized study
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Hari Bahadur KC
Anil Shrestha
Ganesh Bhakta Acharya
Robin Bahadur Basnet
Arvind Kumar Shah
Parash Mani Shrestha
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Abstract
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Purpose: This study aimed to compare the safety and efficacy of tamsulosin and tadalafil as medical expulsive therapy for distal ureteral stones.
Materials and Methods: This prospective randomized study was conducted at the Department of Urology of Bir Hospital over a period of 12 months in patients with distal ureteral stones sized 5 to 10 mm. Patients were randomly divided into 2 groups: group A received tamsulosin 0.4 mg and group B received tadalafil 10 mg at bedtime for 2 weeks. Stone expulsion rate, number of ureteric colic episodes and pain score, analgesic requirements, and adverse drug effects were noted in both groups. Statistical analyses were performed by using Student t-test and chi-square test.
Results: Altogether 85 patients, 41 in group A and 44 in group B, were enrolled in the study. The patients' average age was 31.72±12.63 years, and the male-to-female ratio was 1.5:1. Demographic profiles, stone size, and baseline investigations were comparable between the 2 groups. The stone expulsion rate was significantly higher in the tadalafil group than in the tamsulosin group (84.1% vs. 61.0%, p=0.017). Although the occurrence of side effects was higher with tadalafil, this difference was not significant (p=0.099). There were no serious adverse effects.
Conclusions: Tadalafil has a significantly higher stone expulsion rate than tamsulosin when used as a medical expulsive therapy for distal ureteral stones sized 5?10 mm. Both drugs are safe, effective, and well tolerated with minor side effects.
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KEYWORD
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Tadalafil, Tamsulosin, Ureteral calculi
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